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Here, we measured the in vivo activity of CA1PCs using two-photon [Ca2+] imaging in head-restrained mice during navigation in a virtual corridor and then performed in vitro patch-clamp recording to probe their intrinsic electrical properties and anatomical investigation to characterize their input synapses. The active and passive electrical properties of PCs were similar between PCs with different prior in vivo activities. Perisomatic inhibitory synapse density was also comparable among PCs. The average dendritic spine density and spine head area did not correlate with the mean in vivo activity of PCs, but the size of the spines of place cells was significantly larger compared to that of silent cells. Our results are consistent with excitatory synaptic plasticity as a major mechanism underlying spatially tuned activity of place cells in hippocampal networks."},"author":[{"authorName":"Heredi, Judit","authorAffiliation":"HUN-REN Institute of Experimental Medicine"},{"authorName":"Olah, Gaspar","authorAffiliation":"HUN-REN Institute of Experimental Medicine"},{"authorName":"Sumegi, Mate","authorAffiliation":"HUN-REN Institute of Experimental Medicine"},{"authorName":"Lukacs, Istvan Paul","authorAffiliation":"HUN-REN Institute of Experimental Medicine"},{"authorName":"Aldahabi, Mohammad","authorAffiliation":"HUN-REN Institute of Experimental Medicine"},{"authorName":"Ujfalussy, Balazs","authorAffiliation":"HUN-REN Institute of Experimental Medicine"},{"authorName":"Makara, Judit","authorAffiliation":"HUN-REN Institute of Experimental Medicine"},{"authorName":"Nusser, Nusser","authorAffiliation":"HUN-REN Institute of Experimental Medicine"}],"datasetContact":{"datasetContactName":"Nusser, Zoltan","datasetContactAffiliation":"HUN-REN Institute of Experimental Medicine","datasetContactEmail":"zoltan.nusser@koki.hun-ren.hu"},"dateOfDeposit":"2025-03-10","subject":"Medicine, Health and Life Sciences","title":"Increased excitatory synapse size in hippocampal place cells compared to silent cells","depositor":"Sümegi, Máté","@id":"https://hdl.handle.net/21.15109/ARP/JELBUI","@type":["ore:Aggregation","schema:Dataset"],"schema:version":"1.0","schema:name":"Increased excitatory synapse size in hippocampal place cells compared to silent cells","schema:dateModified":"2025-03-10 15:57:29.564","schema:datePublished":"2025-03-10","schema:creativeWorkStatus":"RELEASED","schema:license":"http://creativecommons.org/licenses/by-nc/4.0","dvcore:fileTermsOfAccess":{"dvcore:fileRequestAccess":true},"schema:includedInDataCatalog":"ARP","schema:isPartOf":{"schema:name":"Nusser Lab","@id":"https://repo.researchdata.hu/dataverse/nusser_lab","schema:description":"https://koki.hun-ren.hu/researchgroups/research-group-for-cellular-neurophysiology","schema:isPartOf":{"schema:name":"Institute of Experimental Medicine (KOKI)","@id":"https://repo.researchdata.hu/dataverse/koki","schema:description":"Dataverse for the Institute of Experimental Medicine.","schema:isPartOf":{"schema:name":"Hungarian Research Network","@id":"https://repo.researchdata.hu/dataverse/hun-ren","schema:description":"<h2>A HUN-REN Magyar Kutatási Hálózat intézményi tárolója</h2>\nA HUN-REN Magyar Kutatási Hálózat a magyar tudományos élet alappillérét jelentő kutatási hálózat. 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