{"id":1001220,"identifier":"ARP/LOEJKK","persistentUrl":"https://hdl.handle.net/21.15109/ARP/LOEJKK","protocol":"hdl","authority":"21.15109","publisher":"ARP","publicationDate":"2025-10-30","storageIdentifier":"s3-sztaki://21.15109/ARP/LOEJKK","metadataLanguage":"en","datasetVersion":{"id":80872,"datasetId":1001220,"datasetPersistentId":"hdl:21.15109/ARP/LOEJKK","storageIdentifier":"s3-sztaki://21.15109/ARP/LOEJKK","versionNumber":1,"versionMinorNumber":1,"versionState":"RELEASED","lastUpdateTime":"2025-11-05T15:30:08Z","releaseTime":"2025-11-05T15:30:08Z","createTime":"2025-11-04T13:06:55Z","publicationDate":"2025-10-30","citationDate":"2025-10-30","license":{"name":"CC BY-NC 4.0","uri":"http://creativecommons.org/licenses/by-nc/4.0","iconUri":"https://licensebuttons.net/l/by-nc/4.0/88x31.png"},"fileAccessRequest":true,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Phylogenetic dataset of fowl adenovirus strains circulating in Bangladesh in 2024"},{"typeName":"title_hu","multiple":false,"typeClass":"primitive","value":"2024-ben Bangladesben keringő tyúk-adenovírus törzsek filogenetikai adatkészlete"},{"typeName":"otherId","multiple":true,"typeClass":"compound","value":[{"otherIdAgency":{"typeName":"otherIdAgency","multiple":false,"typeClass":"primitive","value":"DOI"},"otherIdValue":{"typeName":"otherIdValue","multiple":false,"typeClass":"primitive","value":"10.5158/arp/loejkk"}}]},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Máté, Lilla Katalin"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"HUN-REN Veterinary Medical Research Institute"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Kaján, Győző László"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"HUN-REN Veterinary Medical Research Institute"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0001-8213-8238"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Kaján, Győző László"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"HUN-REN Veterinary Medical Research Institute"},"datasetContactEmail":{"typeName":"datasetContactEmail","multiple":false,"typeClass":"primitive","value":"kajan.gyozo@vmri.hu"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"Fowl adenovirus serotype 8b (FAdV-8b) is a major cause of inclusion body hepatitis (IBH) and significant economic losses in the Bangladeshi poultry industry. In this study, FAdV-8b was identified by PCR and sequencing in multiple organs of naturally infected commercial broiler and broiler breeder flocks. Gross and histopathological lesions included enlarged, friable livers with necrotic foci, hydropericardium, and characteristic intranuclear inclusion bodies in the liver, kidney, spleen, and thymus. Phylogenetic analysis confirmed that the detected FAdV-8b strains are closely related to other Bangladeshi isolates. Notably, natural infection resulted in significant upregulation of proinflammatory cytokines (IL-6, IL-18, TNF-α) and antiviral IFN-γ, particularly in the liver and spleen, suggesting a strong innate immune response associated with tissue pathology. These findings establish FAdV-8b as the predominant IBH pathogen in Bangladesh and underscore the need for ongoing surveillance and targeted control strategies to mitigate its impact on poultry health and production.\nNovel sequences were deposited in the NCBI GenBank database under the accession numbers PV189408-PV189410."},"dsDescriptionDate":{"typeName":"dsDescriptionDate","multiple":false,"typeClass":"primitive","value":"2025-05-13"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Agricultural Sciences"]},{"typeName":"dsDescription_hu","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue_hu":{"typeName":"dsDescriptionValue_hu","multiple":false,"typeClass":"primitive","value":"A tyúk-adenovírus 8b (FAdV-8b) a sejtzárványos májgyulladás egyik fő kórokozója, és jelentős gazdasági veszteségeket okoz a bangladesi baromfiiparban. A jelen vizsgálatban a FAdV-8b-t PCR-rel és szekvenálással azonosították fertőzött broilerek és szülőpárok több szervében. A makroszkópos és szövettani elváltozások között megnagyobbodott, törékeny, elhalásos gócokat tartalmazó májak, hydropericardium, valamint jellegzetes intranukleáris zárványtestek szerepeltek a májban, vesében, lépben és csecsemőmirigyben. A filogenetikai elemzés megerősítette, hogy a kimutatott FAdV-8b törzsek szorosan rokonok más bangladesi izolátumokkal. Figyelemre méltó, hogy a természetes fertőzés jelentős mértékben fokozta a gyulladásos citokinek (IL-6, IL-18, TNF-α) és az antivirális IFN-γ expresszióját, különösen a májban és a lépben, ami erőteljes, a szövetkárosodással összefüggő veleszületett immunválaszra utal.\nEredményeink megerősítik, hogy a FAdV-8b a Bangladesben előforduló sejtzárványos májgyulladás legfontosabb kórokozója, és hangsúlyozzák a folyamatos járványügyi megfigyelés, valamint a célzott védekezési stratégiák szükségességét a betegség baromfi-egészségre és termelésre gyakorolt hatásának mérséklése érdekében.\nAz újonnan meghatározott szekvenciákat az NCBI GenBank adatbázisba helyeztük el PV189408–PV189410 hozzáférési számok alatt."}}]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"fowl adenovirus 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