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Salvatore"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Istituto Zooprofilattico Sperimentale delle Venezie"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0003-3258-172X"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Lysnyansky, Inna"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Department of Avian Diseases, Kimron Veterinary Institute"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-6923-3676"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Kovács, László"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"University of Veterinary Medicine Budapest"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0009-0009-9281-2543"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Gyuranecz, Miklós"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Veterinary Medical Research Institute"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0001-9085-5923"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Kreizinger, Zsuzsa"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Veterinary Medical Research Institute"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-6365-0719"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Kreizinger, Zsuzsa"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"Veterinary Medical Research Institute"},"datasetContactEmail":{"typeName":"datasetContactEmail","multiple":false,"typeClass":"primitive","value":"kreizinger.zsuzsa@vmri.hu"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"<i>Mycoplasma iowae</i> is an economically significant pathogen that causes reduced hatchability, late embryo mortality and leg deformities, chondrodystrophy and skeletal lesions in poults. While prevention is essential in the control of infection, the appropriate administration of antibiotics may reduce economic losses during outbreaks. As a first step in the exploration of antimicrobial resistance mechanisms in <i>M. iowae</i>, target modification and efflux pump activity were examined in the present study. Point mutations were analyzed in previously described antibiotic binding sites in the whole genome sequences of 99 <i>M. iowae</i> strains. Mismatch amplification mutation assays (MAMAs) were designed and validated for the differentiation of mutations corresponding to elevated minimum inhibitory concentration (MIC) values for fluoroquinolones. Broth microdilution assays were performed to evaluate the effect of efflux pump inhibitors. In the presence of orthovanadate (OV), MIC values were significantly lower than in the absence of OV for spiramycin, tilmicosin, tylosin and oxytetracycline, which may indicate the presence of an active efflux system in <i>M. iowae</i>. Putative promoter regions of efflux-related genes were predicted and characterized. Genetic mutations, previously described in other bacteria, were described to be associated with elevated fluoroquinolone, macrolide and lincomycin MICs in <i>M. iowae</i>, although certain resistant phenotypes remained unexplained, promoting future examinations for deeper insights. The developed MAMAs may support rapid identification of <i>M. iowae</i> strains with elevated MIC values for fluoroquinolones. The better understanding of the efflux pump mechanisms enables the development of alternative methods for the support of therapy against this pathogen."},"dsDescriptionDate":{"typeName":"dsDescriptionDate","multiple":false,"typeClass":"primitive","value":"2026-06-11"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Agricultural Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Mycoplasma iowae"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Antimicrobial resistance"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Efflux pumps"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Mismatch amplification mutation assay (MAMA)"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Orthovanadate"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Turkey pathogen"}}]},{"typeName":"dsDescription_hu","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue_hu":{"typeName":"dsDescriptionValue_hu","multiple":false,"typeClass":"primitive","value":"A <i>Mycoplasma iowae</i> gazdasági szempontból jelentős kórokozó, amely csökkent keltethetőséget, késői embrióelhalást, valamint a napospulykák lábdeformitását, chondrodystrophiáját és csontvázrendszeri elváltozásait okozza. Bár a fertőzés elleni védekezés alapvető fontosságú, a megfelelő antibiotikum-kezelés járványkitörések során mérsékelheti a gazdasági veszteségeket. Az antimikrobiális rezisztencia mechanizmusainak feltárása felé tett első lépésként jelen vizsgálat a célmolekula-módosulás és az effluxpumpák aktivitásának szerepét értékelte <i>M. iowae</i> törzsekben.\nA korábban leírt antibiotikum-kötőhelyeken előforduló pontmutációkat 99 <i>M. iowae</i> törzs teljes genomjának szekvenciaadatai alapján vizsgáltuk. Fluorokinolonokkal szembeni emelkedett minimális gátló koncentrációval (MIC) összefüggésbe hozható mutációk kimutatására mismatch amplification mutation assay (MAMA) módszereket terveztünk és validáltunk. Az effluxpumpa-gátlók hatásának értékelésére húsleves-mikrodilúciós vizsgálatokat végeztünk.\nOrto-vanadát (OV) jelenlétében a spiramicin, tilmikozin, tilozin és oxitetraciklin MIC-értékei szignifikánsan alacsonyabbak voltak, mint OV hiányában, ami aktív effluxrendszer jelenlétére utalhat <i>M. iowae</i>-ban. Az effluxhoz kapcsolódó gének feltételezett promóterrégióit előre jeleztük és jellemeztük. Számos olyan genetikai mutációt azonosítottunk, amelyeket más baktériumfajokban korábban már összefüggésbe hoztak a fluorokinolonokkal, makrolidokkal és linkomicinnel szembeni emelkedett MIC-értékekkel, és amelyek <i>M. iowae</i>-ban is kapcsolatot mutattak a csökkent érzékenységgel. Ugyanakkor egyes rezisztens fenotípusok genetikai háttere továbbra sem tisztázott, ami további vizsgálatok szükségességét veti fel.\nA kifejlesztett MAMA módszerek lehetővé tehetik az emelkedett fluorokinolon-MIC-értékű <i>M. iowae</i> törzsek gyors azonosítását. Az effluxpumpa-mechanizmusok jobb megismerése pedig hozzájárulhat olyan alternatív megközelítések kidolgozásához, amelyek támogatják az e kórokozó elleni hatékony terápiás beavatkozásokat."},"dsDescriptionDate_hu":{"typeName":"dsDescriptionDate_hu","multiple":false,"typeClass":"primitive","value":"2026-06-11"}}]},{"typeName":"publication","multiple":true,"typeClass":"compound","value":[{"publicationRelationType":{"typeName":"publicationRelationType","multiple":false,"typeClass":"controlledVocabulary","value":"IsSupplementTo"},"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"Identification and detection of genetic markers associated with antimicrobial susceptibility and evaluation of efflux pump mechanisms in Mycoplasma iowae\nBuni D, Kovács ÁB, Wehmann E, Grózner D, Bányai K, et al. (2026) Identification and detection of genetic markers associated with antimicrobial susceptibility and evaluation of efflux pump mechanisms in Mycoplasma iowae. PLOS ONE 21(4): e0347345"},"publicationIDType":{"typeName":"publicationIDType","multiple":false,"typeClass":"controlledVocabulary","value":"doi"},"publicationIDNumber":{"typeName":"publicationIDNumber","multiple":false,"typeClass":"primitive","value":"10.1371/journal.pone.0347345"},"publicationURL":{"typeName":"publicationURL","multiple":false,"typeClass":"primitive","value":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0347345"}}]},{"typeName":"language","multiple":true,"typeClass":"controlledVocabulary","value":["English"]},{"typeName":"grantNumber","multiple":true,"typeClass":"compound","value":[{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"National Research, Development and Innovation Office"},"grantNumberValue":{"typeName":"grantNumberValue","multiple":false,"typeClass":"primitive","value":"FK21 (137809)"}},{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"National Research, Development and Innovation Office"},"grantNumberValue":{"typeName":"grantNumberValue","multiple":false,"typeClass":"primitive","value":"TKP2021-EGA-01"}},{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"Eötvös Loránd Research Network"},"grantNumberValue":{"typeName":"grantNumberValue","multiple":false,"typeClass":"primitive","value":"SA-27/2021"}},{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"Recovery and Resilience Facility"},"grantNumberValue":{"typeName":"grantNumberValue","multiple":false,"typeClass":"primitive","value":"RRF-2.3.1-21-2022-00001"}},{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"Recovery and Resilience Facility"},"grantNumberValue":{"typeName":"grantNumberValue","multiple":false,"typeClass":"primitive","value":"RRF-2.3.1-21-2022-00006"}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Kaján, Győző László"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2026-06-11"},{"typeName":"relatedDatasets","multiple":true,"typeClass":"primitive","value":["NCBI BioProject ID: PRJNA975348"]}]}},"files":[{"description":"readme file","label":"readme.md","restricted":false,"version":1,"datasetVersionId":81077,"dataFile":{"id":2164320,"persistentId":"hdl:21.15109/ARP/QM0ZUO/CLDWTU","pidURL":"https://hdl.handle.net/21.15109/ARP/QM0ZUO/CLDWTU","filename":"readme.md","contentType":"text/markdown","friendlyType":"Markdown Text","filesize":13196,"description":"readme file","storageIdentifier":"s3-sztaki://concorda:19ebbe4cf25-b0a81154d628","rootDataFileId":-1,"md5":"976f12567e669fba1010212e895b47c1","checksum":{"type":"MD5","value":"976f12567e669fba1010212e895b47c1"},"tabularData":false,"creationDate":"2026-06-12","publicationDate":"2026-06-12","lastUpdateTime":"2026-06-12T13:06:13Z","fileAccessRequest":true}},{"description":"This table contains information on 99 *M. iowae* clinical isolates and strains, including strain designation, country of origin, host species, serotype, minimum inhibitory concentrations (MIC) for enrofloxacin, erythromycin, spiramycin, tilmicosin, tylosin, and lincomycin. 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