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Part 1: Document Description
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Citation |
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Title: |
Phylogenetic dataset of fowl adenovirus strains circulating in Bangladesh in 2024 |
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Identification Number: |
hdl:21.15109/ARP/LOEJKK |
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Distributor: |
ARP |
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Date of Distribution: |
2025-10-30 |
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Version: |
1 |
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Bibliographic Citation: |
Máté, Lilla Katalin; Kaján, Győző László, 2025, "Phylogenetic dataset of fowl adenovirus strains circulating in Bangladesh in 2024", https://hdl.handle.net/21.15109/ARP/LOEJKK, ARP, V1 |
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Citation |
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Title: |
Phylogenetic dataset of fowl adenovirus strains circulating in Bangladesh in 2024 |
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Identification Number: |
hdl:21.15109/ARP/LOEJKK |
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Identification Number: |
10.5158/arp/loejkk |
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Authoring Entity: |
Máté, Lilla Katalin (HUN-REN Veterinary Medical Research Institute) |
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Kaján, Győző László (HUN-REN Veterinary Medical Research Institute) |
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Distributor: |
ARP |
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Access Authority: |
Kaján, Győző László |
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Depositor: |
Kaján, Győző László |
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Date of Deposit: |
2025-05-13 |
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Holdings Information: |
https://hdl.handle.net/21.15109/ARP/LOEJKK |
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Study Scope |
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Keywords: |
Agricultural Sciences, fowl adenovirus 8b, inclusion body hepatitis, innate immune response, Bangladesh, chicken |
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Abstract: |
Fowl adenovirus serotype 8b (FAdV-8b) is a major cause of inclusion body hepatitis (IBH) and significant economic losses in the Bangladeshi poultry industry. In this study, FAdV-8b was identified by PCR and sequencing in multiple organs of naturally infected commercial broiler and broiler breeder flocks. Gross and histopathological lesions included enlarged, friable livers with necrotic foci, hydropericardium, and characteristic intranuclear inclusion bodies in the liver, kidney, spleen, and thymus. Phylogenetic analysis confirmed that the detected FAdV-8b strains are closely related to other Bangladeshi isolates. Notably, natural infection resulted in significant upregulation of proinflammatory cytokines (IL-6, IL-18, TNF-α) and antiviral IFN-γ, particularly in the liver and spleen, suggesting a strong innate immune response associated with tissue pathology. These findings establish FAdV-8b as the predominant IBH pathogen in Bangladesh and underscore the need for ongoing surveillance and targeted control strategies to mitigate its impact on poultry health and production. Novel sequences were deposited in the NCBI GenBank database under the accession numbers PV189408-PV189410. |
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Country: |
Bangladesh |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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Related Studies |
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http://www.ncbi.nlm.nih.gov/nucest?term=PV189408:PV189410[accn] |
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Related Publications |
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Citation |
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Title: |
Molecular characterization, pathology and innate cytokine responses associated with fowl adenovirus 8b in commercial chicken flocks in Bangladesh |
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Identification Number: |
10.1016/j.tvjl.2025.106472 |
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Bibliographic Citation: |
Molecular characterization, pathology and innate cytokine responses associated with fowl adenovirus 8b in commercial chicken flocks in Bangladesh |
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readme.txt |
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text/plain |
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hex_prot_al.fasta |
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hex_prot_al_edited.fasta |
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hex_prot_al_edited.tre |
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hex_prot_al_edited_model_selection.csv |
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pol_prot_al_trimmed.tre |
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